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4jnt

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==Crystal structure of the ectodomain of Bovine viral diarrhea virus 1 E2 envelope protein==
==Crystal structure of the ectodomain of Bovine viral diarrhea virus 1 E2 envelope protein==
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<StructureSection load='4jnt' size='340' side='right' caption='[[4jnt]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
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<StructureSection load='4jnt' size='340' side='right'caption='[[4jnt]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jnt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JNT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jnt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.09&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jnt RCSB], [http://www.ebi.ac.uk/pdbsum/4jnt PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnt OCA], [https://pdbe.org/4jnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jnt RCSB], [https://www.ebi.ac.uk/pdbsum/4jnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jnt ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_BVDVN POLG_BVDVN] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (Probable).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> Uncleaved NS2-3 is required for production of infectious virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS4A is a cofactor for the NS3 protease activity (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4jnt" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bovine viral diarrhea virus 1]]
[[Category: Bovine viral diarrhea virus 1]]
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[[Category: Li, Y]]
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[[Category: Large Structures]]
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[[Category: Modis, Y]]
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[[Category: Li Y]]
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[[Category: Wang, J]]
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[[Category: Modis Y]]
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[[Category: Bvdv1]]
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[[Category: Wang J]]
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[[Category: E2]]
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[[Category: E2 envelope protein]]
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[[Category: Viral envelope protein]]
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[[Category: Viral membrane fusion]]
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[[Category: Viral protein]]
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[[Category: Viral surface membrane]]
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Current revision

Crystal structure of the ectodomain of Bovine viral diarrhea virus 1 E2 envelope protein

PDB ID 4jnt

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