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4m1j

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==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==
==Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue==
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<StructureSection load='4m1j' size='340' side='right' caption='[[4m1j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4m1j' size='340' side='right'caption='[[4m1j]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M1J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M1J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B0S:TRIDECYLBORONIC+ACID'>B0S</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA2385, pvdQ, qsc112 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]), pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [https://pdbe.org/4m1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [https://www.ebi.ac.uk/pdbsum/4m1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m1j ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m1j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m1j RCSB], [http://www.ebi.ac.uk/pdbsum/4m1j PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4m1j" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acyl-homoserine-lactone acylase]]
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Clevenger, K]]
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[[Category: Clevenger K]]
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[[Category: Er, J]]
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[[Category: Er J]]
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[[Category: Fast, W L]]
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[[Category: Fast WL]]
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[[Category: Liu, D]]
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[[Category: Liu D]]
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[[Category: Wu, R]]
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[[Category: Wu R]]
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[[Category: Acylase]]
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[[Category: Boronic acid]]
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[[Category: Heterodimer]]
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[[Category: Hydrolase]]
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[[Category: Secreted]]
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[[Category: Transition state analogue]]
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Current revision

Crystal structure of Pseudomonas aeruginosa PvdQ in complex with a transition state analogue

PDB ID 4m1j

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