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4klm

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==DNA polymerase beta matched product complex with Mg2+, 11 h==
==DNA polymerase beta matched product complex with Mg2+, 11 h==
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<StructureSection load='4klm' size='340' side='right' caption='[[4klm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4klm' size='340' side='right'caption='[[4klm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4klm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4klm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.747&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kld|4kld]], [[4kle|4kle]], [[4klf|4klf]], [[4klg|4klg]], [[4klh|4klh]], [[4kli|4kli]], [[4klj|4klj]], [[4kll|4kll]], [[4klo|4klo]], [[4klp|4klp]], [[4klq|4klq]], [[4kls|4kls]], [[4klt|4klt]], [[4klu|4klu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klm OCA], [https://pdbe.org/4klm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klm RCSB], [https://www.ebi.ac.uk/pdbsum/4klm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klm RCSB], [http://www.ebi.ac.uk/pdbsum/4klm PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4klm" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Beard, W A]]
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[[Category: Large Structures]]
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[[Category: Freudenthal, B D]]
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[[Category: Beard WA]]
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[[Category: Shock, D D]]
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[[Category: Freudenthal BD]]
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[[Category: Wilson, S H]]
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[[Category: Shock DD]]
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[[Category: Dna polymerase]]
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[[Category: Wilson SH]]
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[[Category: Lyase-dna complex]]
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[[Category: Transferase]]
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Current revision

DNA polymerase beta matched product complex with Mg2+, 11 h

PDB ID 4klm

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