3ix0

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==Crystal structure of human seminal plasma protein PSP94==
==Crystal structure of human seminal plasma protein PSP94==
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<StructureSection load='3ix0' size='340' side='right' caption='[[3ix0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3ix0' size='340' side='right'caption='[[3ix0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ix0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ix0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix0 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix0 OCA], [https://pdbe.org/3ix0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix0 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[http://omim.org/entry/611928 611928]]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
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[https://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN] Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13) [MIM:[https://omim.org/entry/611928 611928]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/MSMB_HUMAN MSMB_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ix0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ix0" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jagtap, D D]]
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[[Category: Large Structures]]
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[[Category: Kumar, A]]
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[[Category: Jagtap DD]]
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[[Category: Kumar, M]]
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[[Category: Kumar A]]
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[[Category: Mahale, S D]]
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[[Category: Kumar M]]
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[[Category: Antitumor protein]]
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[[Category: Mahale SD]]
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[[Category: Apoptosis]]
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[[Category: Beta sheet]]
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[[Category: Disulfide bond]]
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[[Category: Greek key motif]]
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[[Category: Protein binding]]
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[[Category: Secreted]]
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Current revision

Crystal structure of human seminal plasma protein PSP94

PDB ID 3ix0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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