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4c7b

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==Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide==
==Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide==
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<StructureSection load='4c7b' size='340' side='right' caption='[[4c7b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4c7b' size='340' side='right'caption='[[4c7b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C7B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BVB:5-[(E)-2-(4-BROMOPHENYL)ETHENYL]BENZENE-1,3-DIOL'>BVB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVB:5-[(E)-2-(4-BROMOPHENYL)ETHENYL]BENZENE-1,3-DIOL'>BVB</scene>, <scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c78|4c78]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7b OCA], [https://pdbe.org/4c7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c7b RCSB], [https://www.ebi.ac.uk/pdbsum/4c7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c7b ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c7b RCSB], [http://www.ebi.ac.uk/pdbsum/4c7b PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4c7b" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Gertz, M]]
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[[Category: Large Structures]]
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[[Category: Nguyen, G T.T]]
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[[Category: Synthetic construct]]
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[[Category: Steegborn, C]]
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[[Category: Gertz M]]
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[[Category: Weyand, M]]
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[[Category: Nguyen GTT]]
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[[Category: Activation]]
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[[Category: Steegborn C]]
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[[Category: Aging]]
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[[Category: Weyand M]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-peptide complex]]
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[[Category: Inhibitor]]
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[[Category: Metabolic sensor]]
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[[Category: Metabolism]]
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[[Category: Resveratrol]]
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[[Category: Sirt1]]
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[[Category: Sirtuin]]
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Current revision

Complex of human Sirt3 with Bromo-Resveratrol and Fluor-De-Lys peptide

PDB ID 4c7b

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