4o9y

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==Crystal Structure of TcdA1==
==Crystal Structure of TcdA1==
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<StructureSection load='4o9y' size='340' side='right' caption='[[4o9y]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='4o9y' size='340' side='right'caption='[[4o9y]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4o9y]] is a 10 chain structure. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw2 1vw2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4o9y]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw1 1vw1] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vw2 1vw2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9Y FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o9x|4o9x]], [[1vw1|1vw1]], [[1vw2|1vw2]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.502&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9y RCSB], [http://www.ebi.ac.uk/pdbsum/4o9y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9y OCA], [https://pdbe.org/4o9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9y RCSB], [https://www.ebi.ac.uk/pdbsum/4o9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9y ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9RN43_PHOLU Q9RN43_PHOLU]
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Tripartite Tc toxin complexes of bacterial pathogens perforate the host membrane and translocate toxic enzymes into the host cell, including in humans. The underlying mechanism is complex but poorly understood. Here we report the first, to our knowledge, high-resolution structures of a TcA subunit in its prepore and pore state and of a complete 1.7 megadalton Tc complex. The structures reveal that, in addition to a translocation channel, TcA forms four receptor-binding sites and a neuraminidase-like region, which are important for its host specificity. pH-induced opening of the shell releases an entropic spring that drives the injection of the TcA channel into the membrane. Binding of TcB/TcC to TcA opens a gate formed by a six-bladed beta-propeller and results in a continuous protein translocation channel, whose architecture and properties suggest a novel mode of protein unfolding and translocation. Our results allow us to understand key steps of infections involving Tc toxins at the molecular level.
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Mechanism of Tc toxin action revealed in molecular detail.,Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O, Vetter IR, Aktories K, Raunser S Nature. 2014 Apr 3;508(7494):61-5. doi: 10.1038/nature13015. Epub 2014 Feb 23. PMID:24572368<ref>PMID:24572368</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aktories, K]]
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[[Category: Large Structures]]
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[[Category: Efremov, R G]]
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[[Category: Photorhabdus luminescens]]
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[[Category: Gatsogiannis, C]]
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[[Category: Aktories K]]
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[[Category: Hofnagel, O]]
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[[Category: Efremov RG]]
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[[Category: Lang, A E]]
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[[Category: Gatsogiannis C]]
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[[Category: Meusch, D]]
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[[Category: Hofnagel O]]
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[[Category: Raunser, S]]
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[[Category: Lang AE]]
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[[Category: Vetter, I R]]
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[[Category: Meusch D]]
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[[Category: Pore-forming]]
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[[Category: Raunser S]]
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[[Category: Tc toxin]]
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[[Category: Vetter IR]]
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[[Category: Toxin]]
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[[Category: Transmembrane]]
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Current revision

Crystal Structure of TcdA1

PDB ID 4o9y

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