4n08

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==Structure of Trypanosoma brucei brucei adenosine kinase (apo)==
==Structure of Trypanosoma brucei brucei adenosine kinase (apo)==
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<StructureSection load='4n08' size='340' side='right' caption='[[4n08]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4n08' size='340' side='right'caption='[[4n08]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n08]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryb2 Tryb2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N08 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N08 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n09|4n09]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb927.6.2360 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=999953 TRYB2])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n08 OCA], [https://pdbe.org/4n08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n08 RCSB], [https://www.ebi.ac.uk/pdbsum/4n08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n08 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_kinase Adenosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n08 RCSB], [http://www.ebi.ac.uk/pdbsum/4n08 PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q584S0_TRYB2 Q584S0_TRYB2]
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Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation. The structures of T. brucei brucei adenosine kinase (TbAK) in its unliganded open conformation and complexed with adenosine and ADP in the closed conformation are both reported to 2.6 A resolution. The structures give insight into the binding mode of the substrates and the conformational change induced upon substrate binding. This information can be used to guide the improvement of cytotoxic substrate analogues as potential antitrypanosomal drugs.
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Structures of adenosine kinase from Trypanosoma brucei brucei.,Timm J, Gonzalez-Pacanowska D, Wilson KS Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):34-9. doi:, 10.1107/S2053230X13033621. Epub 2013 Dec 24. PMID:24419613<ref>PMID:24419613</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Adenosine kinase|Adenosine kinase]]
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*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosine kinase]]
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[[Category: Large Structures]]
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[[Category: Tryb2]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Timm, J]]
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[[Category: Timm J]]
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[[Category: Wilson, K S]]
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[[Category: Wilson KS]]
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[[Category: Anion hole]]
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[[Category: Transferase]]
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Current revision

Structure of Trypanosoma brucei brucei adenosine kinase (apo)

PDB ID 4n08

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