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2m1h

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==Solution structure of a PWWP domain from Trypanosoma brucei==
==Solution structure of a PWWP domain from Trypanosoma brucei==
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<StructureSection load='2m1h' size='340' side='right' caption='[[2m1h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2m1h' size='340' side='right'caption='[[2m1h]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m1h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M1H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1H FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb927.2.3580 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma (Trypanozoon) brucei])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m1h RCSB], [http://www.ebi.ac.uk/pdbsum/2m1h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1h OCA], [https://pdbe.org/2m1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1h RCSB], [https://www.ebi.ac.uk/pdbsum/2m1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1h ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q586X9_TRYB2 Q586X9_TRYB2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TbTFIIS2-1, one of the two TFIIS homologues of Trypanosome brucei (T. brucei), cooperates with TbTFIIS1 in regulating transcription in T. brcuei. Structurally divergent from other TFIIS homologues from higher organisms, TbTFIIS2-1 contains an additional N-terminal PWWP domain besides other three conserved domains, which may imply potential role of TbTFIIS2-1 in transcription regulation. Here, we determined the solution structure of PWWP domain of TbTFIIS2-1 by NMR spectroscopy, which was the first solution structure of PWWP domain solved in trypanosomatid. In spite of poor sequence similarity between PWWP domains, this domain of TbTFIIS2-1 adopts a conserved 3D-structure, which contains a fi ve-stranded beta-barrel and a C-terminal alpha-helix. Furthermore, we found that TbTFIIS2-1 PWWP domain may be a protein-protein interaction module without the ability of DNA recognition and methyl-group interaction. This article is protected by copyright. All rights reserved.
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Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei.,Wang R, Zhang J, Liao S, Tu X Proteins. 2016 Mar 23. doi: 10.1002/prot.25035. PMID:27005948<ref>PMID:27005948</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2m1h" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Elongation factor|Elongation factor]]
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fan, K]]
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[[Category: Large Structures]]
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[[Category: Liao, S]]
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[[Category: Trypanosoma brucei]]
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[[Category: Tu, X]]
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[[Category: Fan K]]
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[[Category: Wang, R]]
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[[Category: Liao S]]
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[[Category: Zhang, J]]
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[[Category: Tu X]]
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[[Category: Transcription]]
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[[Category: Wang R]]
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[[Category: Transcription factor]]
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[[Category: Zhang J]]

Current revision

Solution structure of a PWWP domain from Trypanosoma brucei

PDB ID 2m1h

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