4mxv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:44, 20 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of Lymphotoxin alpha bound to anti-LTa Fab==
==Structure of Lymphotoxin alpha bound to anti-LTa Fab==
-
<StructureSection load='4mxv' size='340' side='right' caption='[[4mxv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
+
<StructureSection load='4mxv' size='340' side='right'caption='[[4mxv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4mxv]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MXV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4mxv]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MXV FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tnr|1tnr]], [[4mxw|4mxw]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LTA, TNFB, TNFSF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxv OCA], [https://pdbe.org/4mxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mxv RCSB], [https://www.ebi.ac.uk/pdbsum/4mxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mxv ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mxv RCSB], [http://www.ebi.ac.uk/pdbsum/4mxv PDBsum]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
+
[https://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN] Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[https://omim.org/entry/607507 607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN]] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
+
[https://www.uniprot.org/uniprot/TNFB_HUMAN TNFB_HUMAN] Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4mxv" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Monoclonal Antibody|Monoclonal Antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
 +
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
 +
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
 +
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Hymowitz, S G]]
+
[[Category: Large Structures]]
-
[[Category: Yin, J P]]
+
[[Category: Hymowitz SG]]
-
[[Category: Auto-immunity]]
+
[[Category: Yin JP]]
-
[[Category: Cytokine-immune system complex]]
+
-
[[Category: Lymphoid development]]
+
-
[[Category: Lymphotoxin alpha]]
+
-
[[Category: Lymphotoxin beta receptor]]
+
-
[[Category: Tnf]]
+
-
[[Category: Tnfr receptor]]
+
-
[[Category: Tumor immunity]]
+
-
[[Category: Tumor necrosis factor]]
+

Current revision

Structure of Lymphotoxin alpha bound to anti-LTa Fab

PDB ID 4mxv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mxv"
Personal tools