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1t3p

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[[Image:1t3p.gif|left|200px]]
 
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{{Structure
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==Half-sandwich arene ruthenium(II)-enzyme complex==
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|PDB= 1t3p |SIZE=350|CAPTION= <scene name='initialview01'>1t3p</scene>, resolution 1.60&Aring;
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<StructureSection load='1t3p' size='340' side='right'caption='[[1t3p]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=RU7:PARA-CYMENE RUTHENIUM CHLORIDE'>RU7</scene>
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<table><tr><td colspan='2'>[[1t3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3P FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU7:PARA-CYMENE+RUTHENIUM+CHLORIDE'>RU7</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3p OCA], [https://pdbe.org/1t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3p RCSB], [https://www.ebi.ac.uk/pdbsum/1t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15.
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'''Half-sandwich arene ruthenium(II)-enzyme complex'''
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Half-sandwich arene ruthenium(II)-enzyme complex.,McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ Chem Commun (Camb). 2004 Aug 21;(16):1786-7. Epub 2004 Jul 27. PMID:15306883<ref>PMID:15306883</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1t3p" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15.
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*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1T3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3P OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Half-sandwich arene ruthenium(II)-enzyme complex., McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ, Chem Commun (Camb). 2004 Aug 21;(16):1786-7. Epub 2004 Jul 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15306883 15306883]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Lysozyme]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Fishburne K]]
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[[Category: Fishburne, K.]]
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[[Category: Habtemariam A]]
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[[Category: Habtemariam, A.]]
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[[Category: Hunter TM]]
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[[Category: Hunter, T M.]]
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[[Category: McNae IW]]
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[[Category: McNae, I W.]]
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[[Category: Melchart M]]
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[[Category: Melchart, M.]]
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[[Category: Sadler PJ]]
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[[Category: Sadler, P J.]]
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[[Category: Walkinshaw MD]]
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[[Category: Walkinshaw, M D.]]
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[[Category: Wang F]]
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[[Category: Wang, F.]]
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[[Category: ACT]]
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[[Category: CL]]
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[[Category: NA]]
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[[Category: RU7]]
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[[Category: ruthenium]]
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[[Category: tetragonal lysozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:13:23 2008''
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Current revision

Half-sandwich arene ruthenium(II)-enzyme complex

PDB ID 1t3p

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