1tbu

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[[Image:1tbu.gif|left|200px]]
 
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{{Structure
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==Crystal structure of N-terminal domain of yeast peroxisomal thioesterase-1==
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|PDB= 1tbu |SIZE=350|CAPTION= <scene name='initialview01'>1tbu</scene>, resolution 2.20&Aring;
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<StructureSection load='1tbu' size='340' side='right'caption='[[1tbu]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FMT:FORMIC ACID'>FMT</scene>
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<table><tr><td colspan='2'>[[1tbu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBU FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Palmitoyl-CoA_hydrolase Palmitoyl-CoA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.2 3.1.2.2]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE= PTE1, TES1, YJR019C, J1456 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbu OCA], [https://pdbe.org/1tbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbu RCSB], [https://www.ebi.ac.uk/pdbsum/1tbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTE1_YEAST PTE1_YEAST] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbu ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of N-terminal domain of yeast peroxisomal thioesterase-1'''
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1TBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBU OCA].
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[[Category: Large Structures]]
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[[Category: Palmitoyl-CoA hydrolase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Derewenda U]]
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[[Category: Derewenda, U.]]
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[[Category: Derewenda ZS]]
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[[Category: Derewenda, Z S.]]
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[[Category: Devedjiev YD]]
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[[Category: Devedjiev, Y D.]]
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[[Category: Li J]]
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[[Category: Li, J.]]
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[[Category: FMT]]
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[[Category: yeast peroxisomal thioesterase; x-ray structure; domain swapping; iodine soak; sira]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:16:23 2008''
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Current revision

Crystal structure of N-terminal domain of yeast peroxisomal thioesterase-1

PDB ID 1tbu

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