1q01
From Proteopedia
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==Lebetin peptides, a new class of potent aggregation inhibitors== | ==Lebetin peptides, a new class of potent aggregation inhibitors== | ||
| - | <StructureSection load='1q01' size='340' side='right' caption='[[1q01 | + | <StructureSection load='1q01' size='340' side='right'caption='[[1q01]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1q01]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1q01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetinus Macrovipera lebetinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q01 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q01 OCA], [https://pdbe.org/1q01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q01 RCSB], [https://www.ebi.ac.uk/pdbsum/1q01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q01 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LEB_MACLB LEB_MACLB] Lebetins inhibit platelet aggregation induced by thrombin, collagen and PAF-acether. Human platelet aggregation induced by thrombin is inhibited by synthetic lebetin-1-alpha, lebetin-1-beta, lebetin-1-gamma, lebetin-2-alpha and lebetin-2-beta with IC(50) values of 140, 32, 5, 2.5 and 2.8 nM, respectively. Lebetins also inhibit fibrinogen-induced aggregation of alpha-chymotrypsin-treated platelets as well as in vivo collagen-induced thrombocytopenia in rats. Lebetins are not toxic upon intravenous injection into mice and rats.<ref>PMID:11910186</ref> <ref>PMID:8769304</ref> <ref>PMID:9839678</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Macrovipera lebetinus]] |
| - | [[Category: Darbon | + | [[Category: Darbon H]] |
| - | [[Category: | + | [[Category: El Ayeb M]] |
| - | [[Category: Giralt | + | [[Category: Ganzalez MJ]] |
| - | [[Category: Mabrouk | + | [[Category: Giralt E]] |
| - | [[Category: Marrakchi | + | [[Category: Mabrouk K]] |
| - | [[Category: Mosbah | + | [[Category: Marrakchi N]] |
| - | + | [[Category: Mosbah A]] | |
| - | [[Category: Rochat | + | [[Category: Rochat H]] |
| - | [[Category: Sabatier | + | [[Category: Sabatier JM]] |
| - | [[Category: | + | [[Category: Van Rietschoten J]] |
| - | + | ||
Current revision
Lebetin peptides, a new class of potent aggregation inhibitors
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