2lxu
From Proteopedia
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==Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A== | ==Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A== | ||
| - | <StructureSection load='2lxu' size='340' side='right' caption='[[2lxu | + | <StructureSection load='2lxu' size='340' side='right'caption='[[2lxu]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2lxu]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2lxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXU FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxu OCA], [https://pdbe.org/2lxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxu RCSB], [https://www.ebi.ac.uk/pdbsum/2lxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] Precursor T-cell acute lymphoblastic leukemia. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/HNRH1_HUMAN HNRH1_HUMAN] This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).<ref>PMID:11003644</ref> <ref>PMID:16946708</ref> |
==See Also== | ==See Also== | ||
| - | *[[Nucleoprotein|Nucleoprotein]] | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Acton | + | [[Category: Large Structures]] |
| - | [[Category: Everett | + | [[Category: Acton TB]] |
| - | [[Category: Janjua | + | [[Category: Everett JK]] |
| - | [[Category: Kennedy | + | [[Category: Janjua H]] |
| - | [[Category: Kohan | + | [[Category: Kennedy MA]] |
| - | [[Category: Montelione | + | [[Category: Kohan E]] |
| - | + | [[Category: Montelione GT]] | |
| - | [[Category: Pederson | + | [[Category: Pederson K]] |
| - | [[Category: Prestegard | + | [[Category: Prestegard JH]] |
| - | [[Category: Ramelot | + | [[Category: Ramelot TA]] |
| - | [[Category: Shastry | + | [[Category: Shastry R]] |
| - | [[Category: Xiao | + | [[Category: Xiao R]] |
| - | [[Category: Yang | + | [[Category: Yang Y]] |
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Current revision
Solution NMR Structure of the eukaryotic RNA recognition motif, RRM1, from the heterogeneous nuclear ribonucleoprotein H from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8614A
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Categories: Homo sapiens | Large Structures | Acton TB | Everett JK | Janjua H | Kennedy MA | Kohan E | Montelione GT | Pederson K | Prestegard JH | Ramelot TA | Shastry R | Xiao R | Yang Y
