1tlw

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[[Image:1tlw.jpg|left|200px]]
 
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{{Structure
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==Tsx structure complexed with thymidine==
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|PDB= 1tlw |SIZE=350|CAPTION= <scene name='initialview01'>1tlw</scene>, resolution 3.10&Aring;
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<StructureSection load='1tlw' size='340' side='right'caption='[[1tlw]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=THM:THYMIDINE'>THM</scene>
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<table><tr><td colspan='2'>[[1tlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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|GENE= TSX, NUPA, B0411, Z0512, ECS0464, SF0348, S0356 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlw OCA], [https://pdbe.org/1tlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlw RCSB], [https://www.ebi.ac.uk/pdbsum/1tlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlw ProSAT]</span></td></tr>
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</table>
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'''Tsx structure complexed with thymidine'''
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== Function ==
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[https://www.uniprot.org/uniprot/TSX_ECOLI TSX_ECOLI] Constitutes the receptor for colicin K and phage T6, and functions as substrate-specific channel for nucleosides and deoxynucleosides.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Tsx is a nucleoside-specific outer membrane (OM) transporter of Gram-negative bacteria. We present crystal structures of Escherichia coli Tsx in the absence and presence of nucleosides. These structures provide a mechanism for nucleoside transport across the bacterial OM. Tsx forms a monomeric, 12-stranded beta-barrel with a long and narrow channel spanning the outer membrane. The channel, which is shaped like a keyhole, contains several distinct nucleoside-binding sites, two of which are well defined. The base moiety of the nucleoside is located in the narrow part of the keyhole, while the sugar occupies the wider opening. Pairs of aromatic residues and flanking ionizable residues are involved in nucleoside binding. Nucleoside transport presumably occurs by diffusion from one binding site to the next.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlw_consurf.spt"</scriptWhenChecked>
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1TLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLW OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of the bacterial nucleoside transporter Tsx., Ye J, van den Berg B, EMBO J. 2004 Aug 18;23(16):3187-95. Epub 2004 Jul 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15272310 15272310]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlw ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berg, B van den.]]
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[[Category: Ye J]]
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[[Category: Ye, J.]]
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[[Category: Van den Berg B]]
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[[Category: THM]]
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[[Category: beta barrel]]
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[[Category: nucleoside transporter]]
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[[Category: thymidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:20:07 2008''
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Current revision

Tsx structure complexed with thymidine

PDB ID 1tlw

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