1c4e

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==GURMARIN FROM GYMNEMA SYLVESTRE==
==GURMARIN FROM GYMNEMA SYLVESTRE==
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<StructureSection load='1c4e' size='340' side='right' caption='[[1c4e]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1c4e' size='340' side='right'caption='[[1c4e]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1c4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gymnema_sylvestre Gymnema sylvestre]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2gur 2gur]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4E FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gur|2gur]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [http://www.ebi.ac.uk/pdbsum/1c4e PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4e OCA], [https://pdbe.org/1c4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4e RCSB], [https://www.ebi.ac.uk/pdbsum/1c4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4e ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUR_GYMSY GUR_GYMSY] Suppresses strongly the sweet taste responses in the rat with high specificity to sucrose, glucose, glycine, and saccharin. This effect is reversible, but complete recovery of the suppressed responses required at least 3h. Gurmarin showed no effect or only a very weak effect on the sweet taste sensation in humans.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1c4e" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Gymnema sylvestre]]
[[Category: Gymnema sylvestre]]
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[[Category: Dingley, A J]]
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[[Category: Large Structures]]
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[[Category: Fletcher, J I]]
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[[Category: Dingley AJ]]
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[[Category: King, G F]]
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[[Category: Fletcher JI]]
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[[Category: Cystine knot]]
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[[Category: King GF]]
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[[Category: Gurmarin]]
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[[Category: Plant protein]]
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[[Category: Sweet taste suppression]]
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[[Category: Sweet taste transduction]]
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Current revision

GURMARIN FROM GYMNEMA SYLVESTRE

PDB ID 1c4e

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