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Complement regulator-acquiring surface protein
From Proteopedia
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| - | <StructureSection load='4cbe' size='340' side='right' caption='CRASP-2 (PDB code [[ | + | <StructureSection load='4cbe' size='340' side='right' caption='CRASP-2 (PDB code [[4cbe]])' scene=''> |
== Function == | == Function == | ||
| - | '''Complement regulator-acquiring surface protein''' (CRASP) are proteins of the Lyme-disease causing bacteria | + | '''Complement regulator-acquiring surface protein''' (CRASP) are proteins of the Lyme-disease causing bacteria ''Borrelia burgdorferi'' which bind to several human extracellular matrix proteins. For details on '''CRASP-1''' see [[Borrelia burgdorferi Complement Regulator-Acquiring Surface Protein 1]].<ref>PMID:20565259</ref><ref>PMID:24702793</ref> |
== Disease == | == Disease == | ||
Lyme-disease adhesion factors. | Lyme-disease adhesion factors. | ||
| - | == Relevance == | ||
| - | |||
| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
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*CRASP-1 | *CRASP-1 | ||
| - | **[[1w33]], [[1w3z]], [[4bl4]] – BbCRASP-1 extracellular domain- ''Borrelia burgdorferi''<br /> | + | **[[1w33]], [[1w3z]], [[4bl4]], [[5a2u]] – BbCRASP-1 extracellular domain- ''Borrelia burgdorferi''<br /> |
*CRASP-2 | *CRASP-2 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D structures of Complement regulator-acquiring surface protein
Updated on 19-October-2017
References
- ↑ Hallstrom T, Haupt K, Kraiczy P, Hortschansky P, Wallich R, Skerka C, Zipfel PF. Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen. J Infect Dis. 2010 Aug 15;202(3):490-8. doi: 10.1086/653825. PMID:20565259 doi:10.1086/653825
- ↑ Brangulis K, Petrovskis I, Kazaks A, Bogans J, Otikovs M, Jaudzems K, Ranka R, Tars K. Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi. FEBS J. 2014 Apr 7. doi: 10.1111/febs.12808. PMID:24702793 doi:http://dx.doi.org/10.1111/febs.12808
