1uem

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[[Image:1uem.jpg|left|200px]]
 
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{{Structure
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==Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein==
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|PDB= 1uem |SIZE=350|CAPTION= <scene name='initialview01'>1uem</scene>
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<StructureSection load='1uem' size='340' side='right'caption='[[1uem]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1uem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UEM FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= KAZUSA cDNA fh22308 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uem OCA], [https://pdbe.org/1uem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uem RCSB], [https://www.ebi.ac.uk/pdbsum/1uem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uem ProSAT], [https://www.topsan.org/Proteins/RSGI/1uem TOPSAN]</span></td></tr>
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}}
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</table>
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== Disease ==
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'''Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein'''
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[https://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN] Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2) [MIM:[https://omim.org/entry/610878 610878]. VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults.<ref>PMID:17357069</ref> Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
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== Function ==
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[https://www.uniprot.org/uniprot/ROBO2_HUMAN ROBO2_HUMAN] Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
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==Disease==
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== Evolutionary Conservation ==
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Known diseases associated with this structure: Vesicoureteral reflux 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602431 602431]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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1UEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UEM OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ue/1uem_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uem ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: fibronectin type iii]]
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[[Category: immunoglobulin-like beta-sandwich fold]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:31:00 2008''
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Current revision

Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein

PDB ID 1uem

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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