1v5b

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[[Image:1v5b.gif|left|200px]]
 
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{{Structure
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==The Structure Of The Mutant, S225A and E251L, Of 3-Isopropylmalate Dehydrogenase From Bacillus Coagulans==
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|PDB= 1v5b |SIZE=350|CAPTION= <scene name='initialview01'>1v5b</scene>, resolution 2.95&Aring;
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<StructureSection load='1v5b' size='340' side='right'caption='[[1v5b]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1v5b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Weizmannia_coagulans Weizmannia coagulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V5B FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v5b OCA], [https://pdbe.org/1v5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v5b RCSB], [https://www.ebi.ac.uk/pdbsum/1v5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v5b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEU3_WEICA LEU3_WEICA] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v5b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v5b ConSurf].
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<div style="clear:both"></div>
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'''The Structure Of The Mutant, S225A and E251L, Of 3-Isopropylmalate Dehydrogenase From Bacillus Coagulans'''
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==See Also==
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*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1V5B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_coagulans Bacillus coagulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V5B OCA].
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[[Category: Large Structures]]
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[[Category: 3-isopropylmalate dehydrogenase]]
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[[Category: Weizmannia coagulans]]
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[[Category: Bacillus coagulans]]
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[[Category: Fujita K]]
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[[Category: Single protein]]
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[[Category: Minami H]]
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[[Category: Fujita, K.]]
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[[Category: Mizui R]]
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[[Category: Minami, H.]]
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[[Category: Nakamura S]]
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[[Category: Mizui, R.]]
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[[Category: Sekiguchi T]]
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[[Category: Nakamura, S.]]
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[[Category: Suzuki K]]
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[[Category: Sekiguchi, T.]]
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[[Category: Takenaka A]]
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[[Category: Suzuki, K.]]
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[[Category: Tsunoda M]]
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[[Category: Takenaka, A.]]
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[[Category: Tsuzaki S]]
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[[Category: Tsunoda, M.]]
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[[Category: Tsuzaki, S.]]
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[[Category: SO4]]
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[[Category: bacillus coagulan]]
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[[Category: crystal structure]]
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[[Category: homo dimer]]
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[[Category: ipmdh]]
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[[Category: mutant]]
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[[Category: s225a/e251l]]
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[[Category: x-ray analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:40:59 2008''
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Current revision

The Structure Of The Mutant, S225A and E251L, Of 3-Isopropylmalate Dehydrogenase From Bacillus Coagulans

PDB ID 1v5b

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