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1v59

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[[Image:1v59.gif|left|200px]]
 
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{{Structure
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==Crystal structure of yeast lipoamide dehydrogenase complexed with NAD+==
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|PDB= 1v59 |SIZE=350|CAPTION= <scene name='initialview01'>1v59</scene>, resolution 2.20&Aring;
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<StructureSection load='1v59' size='340' side='right'caption='[[1v59]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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<table><tr><td colspan='2'>[[1v59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V59 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Dihydrolipoyl_dehydrogenase Dihydrolipoyl dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.4 1.8.1.4]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v59 OCA], [https://pdbe.org/1v59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v59 RCSB], [https://www.ebi.ac.uk/pdbsum/1v59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v59 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLDH_YEAST DLDH_YEAST] Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. This includes the pyruvate dehydrogenase complex, which catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). Acts also as component of the glycine cleavage system (glycine decarboxylase complex), which catalyzes the degradation of glycine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/1v59_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1v59 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of yeast lipoamide dehydrogenase complexed with NAD+'''
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==See Also==
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*[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1V59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V59 OCA].
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[[Category: Large Structures]]
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[[Category: Dihydrolipoyl dehydrogenase]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Adachi W]]
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[[Category: Adachi, W.]]
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[[Category: Reed LJ]]
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[[Category: Reed, L J.]]
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[[Category: Sekiguchi T]]
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[[Category: Sekiguchi, T.]]
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[[Category: Suzuki K]]
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[[Category: Suzuki, K.]]
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[[Category: Takenaka A]]
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[[Category: Takenaka, A.]]
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[[Category: Tsunoda M]]
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[[Category: Tsunoda, M.]]
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[[Category: FAD]]
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[[Category: NAD]]
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[[Category: PO4]]
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[[Category: 2-oxoacid dehydroganese complex]]
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[[Category: dihydrolipoamide dehydrogenase]]
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[[Category: lipoamide dehydrogenase]]
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[[Category: nad+]]
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[[Category: pyridine nucleotide-disulphide oxidoreductase]]
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[[Category: pyruvate dehydrogenase complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:41:01 2008''
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Current revision

Crystal structure of yeast lipoamide dehydrogenase complexed with NAD+

PDB ID 1v59

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