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4e00

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==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP==
==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP==
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<StructureSection load='4e00' size='340' side='right' caption='[[4e00]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='4e00' size='340' side='right'caption='[[4e00]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4e00]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E00 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4e00]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E00 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0F1:3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>0F1</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tz0|3tz0]], [[3tz2|3tz2]], [[3tz4|3tz4]], [[3tz5|3tz5]], [[4dzy|4dzy]], [[4e01|4e01]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0F1:3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC+ACID'>0F1</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e00 OCA], [https://pdbe.org/4e00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e00 RCSB], [https://www.ebi.ac.uk/pdbsum/4e00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e00 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e00 RCSB], [http://www.ebi.ac.uk/pdbsum/4e00 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
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[https://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chuang, D T]]
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[[Category: Chuang DT]]
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[[Category: Chuang, J L]]
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[[Category: Chuang JL]]
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[[Category: Gui, W J]]
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[[Category: Gui WJ]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Tso, S C]]
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[[Category: Tso SC]]
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[[Category: Wynn, R M]]
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[[Category: Wynn RM]]
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[[Category: Allosteric kinase inhibitor]]
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[[Category: Bergerat nucleotide-binding fold]]
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[[Category: Branched-chain alpha-ketoacid]]
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[[Category: Branched-chain amino acid]]
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[[Category: Diabetes and obesity]]
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[[Category: Ghkl protein kinase]]
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[[Category: Maple syrup urine disease]]
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[[Category: Protein kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/3,6-dichlorobenzo[b]thiophene-2-carboxylic acid complex with ADP

PDB ID 4e00

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