4jhx

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==Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in complex with carbamoylphosphate and arginine==
==Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in complex with carbamoylphosphate and arginine==
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<StructureSection load='4jhx' size='340' side='right' caption='[[4jhx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='4jhx' size='340' side='right'caption='[[4jhx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jhx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JHX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jhx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus_CMCP6 Vibrio vulnificus CMCP6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JHX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CP:PHOSPHORIC+ACID+MONO(FORMAMIDE)ESTER'>CP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h31|4h31]], [[4jfr|4jfr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CP:PHOSPHORIC+ACID+MONO(FORMAMIDE)ESTER'>CP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">argF, VV1_1466 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 VIBVU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jhx OCA], [https://pdbe.org/4jhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jhx RCSB], [https://www.ebi.ac.uk/pdbsum/4jhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jhx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_carbamoyltransferase Ornithine carbamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.3.3 2.1.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jhx RCSB], [http://www.ebi.ac.uk/pdbsum/4jhx PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OTC_VIBVU OTC_VIBVU]] Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis (By similarity).
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[https://www.uniprot.org/uniprot/OTC_VIBVU OTC_VIBVU] Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis (By similarity).
==See Also==
==See Also==
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*[[Ornithine carbamoyltransferase|Ornithine carbamoyltransferase]]
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*[[Ornithine carbamoyltransferase 3D structures|Ornithine carbamoyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ornithine carbamoyltransferase]]
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[[Category: Large Structures]]
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[[Category: Vibvu]]
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[[Category: Vibrio vulnificus CMCP6]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Bacal, P]]
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[[Category: Bacal P]]
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[[Category: Structural genomic]]
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[[Category: Chordia MD]]
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[[Category: Chordia, M D]]
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[[Category: Grabowski M]]
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[[Category: Grabowski, M]]
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[[Category: Grimshaw S]]
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[[Category: Grimshaw, S]]
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[[Category: Minor W]]
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[[Category: Minor, W]]
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[[Category: Shabalin IG]]
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[[Category: Shabalin, I G]]
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[[Category: Shuvalova L]]
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[[Category: Shuvalova, L]]
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[[Category: Winsor J]]
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[[Category: Winsor, J]]
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[[Category: Carbamoylphosphate]]
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[[Category: Csgid]]
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[[Category: L-ornithine]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Transferase]]
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Current revision

Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in complex with carbamoylphosphate and arginine

PDB ID 4jhx

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