4lp8

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==A Novel Open-State Crystal Structure of the Prokaryotic Inward Rectifier KirBac3.1==
==A Novel Open-State Crystal Structure of the Prokaryotic Inward Rectifier KirBac3.1==
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<StructureSection load='4lp8' size='340' side='right' caption='[[4lp8]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
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<StructureSection load='4lp8' size='340' side='right'caption='[[4lp8]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lp8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_31632 Atcc 31632]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LP8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lp8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetospirillum_magnetotacticum Magnetospirillum magnetotacticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LP8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zrs|3zrs]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lp8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lp8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lp8 OCA], [https://pdbe.org/4lp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lp8 RCSB], [https://www.ebi.ac.uk/pdbsum/4lp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lp8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IRK10_MAGMG IRK10_MAGMG]] Inward rectifier potassium channel that mediates potassium uptake into the cell. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification may be achieved by the blockage of outward current by cytoplasmic divalent metal ions and polyamines. Complements an E.coli mutant that is defective in K(+) uptake.<ref>PMID:20876570</ref> <ref>PMID:20564790</ref> <ref>PMID:22231399</ref>
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[https://www.uniprot.org/uniprot/IRK10_MAGMG IRK10_MAGMG] Inward rectifier potassium channel that mediates potassium uptake into the cell. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification may be achieved by the blockage of outward current by cytoplasmic divalent metal ions and polyamines. Complements an E.coli mutant that is defective in K(+) uptake.<ref>PMID:20876570</ref> <ref>PMID:20564790</ref> <ref>PMID:22231399</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4lp8" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 31632]]
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[[Category: Large Structures]]
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[[Category: Bavro, V N]]
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[[Category: Magnetospirillum magnetotacticum]]
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[[Category: Muniz, J R.C]]
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[[Category: Bavro VN]]
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[[Category: Nichols, C G]]
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[[Category: De Zorzi R]]
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[[Category: Sansom, M S.P]]
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[[Category: Muniz JRC]]
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[[Category: Schmidt, M R]]
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[[Category: Nichols CG]]
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[[Category: Tucker, S J]]
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[[Category: Sansom MSP]]
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[[Category: Venien-Bryan, C]]
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[[Category: Schmidt MR]]
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[[Category: Wang, S]]
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[[Category: Tucker SJ]]
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[[Category: Zorzi, R De]]
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[[Category: Venien-Bryan C]]
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[[Category: Zubcevic, L]]
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[[Category: Wang S]]
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[[Category: Membrane]]
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[[Category: Zubcevic L]]
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[[Category: Metal transport]]
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[[Category: Potassium channel]]
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Current revision

A Novel Open-State Crystal Structure of the Prokaryotic Inward Rectifier KirBac3.1

PDB ID 4lp8

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