2mio

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==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A==
==Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A==
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<StructureSection load='2mio' size='340' side='right' caption='[[2mio]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2mio' size='340' side='right'caption='[[2mio]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mio]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIO FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARHGAP10, GRAF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [http://www.ebi.ac.uk/pdbsum/2mio PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mio OCA], [https://pdbe.org/2mio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mio RCSB], [https://www.ebi.ac.uk/pdbsum/2mio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mio ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN]] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
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[https://www.uniprot.org/uniprot/RHG10_HUMAN RHG10_HUMAN] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
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==See Also==
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*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Eletsky, A]]
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[[Category: Large Structures]]
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[[Category: Everett, J K]]
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[[Category: Eletsky A]]
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[[Category: Janjua, H]]
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[[Category: Everett JK]]
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[[Category: Montelione, G T]]
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[[Category: Janjua H]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Pulavarti, S V.S R.K]]
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[[Category: Pulavarti SVSRK]]
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[[Category: Sukumaran, D K]]
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[[Category: Sukumaran DK]]
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[[Category: Szyperski, T]]
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[[Category: Szyperski T]]
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[[Category: Wang, H]]
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[[Category: Wang H]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: Xu, X]]
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[[Category: Xu X]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Unknown function]]
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Current revision

Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A

PDB ID 2mio

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