1w5z

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[[Image:1w5z.gif|left|200px]]
 
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{{Structure
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==AGAO covalent complex with Benzylhydrazine==
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|PDB= 1w5z |SIZE=350|CAPTION= <scene name='initialview01'>1w5z</scene>, resolution 1.86&Aring;
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<StructureSection load='1w5z' size='340' side='right'caption='[[1w5z]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1w5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W5Z FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Amine_oxidase_(copper-containing) Amine oxidase (copper-containing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.6 1.4.3.6]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TY:3-[(3E)-3-(BENZYLHYDRAZONO)-4-HYDROXY-6-OXOCYCLOHEXA-1,4-DIEN-1-YL]-L-ALANINE'>3TY</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w5z OCA], [https://pdbe.org/1w5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w5z RCSB], [https://www.ebi.ac.uk/pdbsum/1w5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w5z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAOX_ARTGO PAOX_ARTGO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/1w5z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w5z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
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'''AGAO COVALENT COMPLEX WITH BENZYLHYDRAZINE'''
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Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.,Langley DB, Trambaiolo DM, Duff AP, Dooley DM, Freeman HC, Guss JM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt, 7):577-83. Epub 2008 Jun 11. PMID:18607080<ref>PMID:18607080</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1w5z" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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1W5Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_globiformis Arthrobacter globiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W5Z OCA].
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*[[Copper amine oxidase 3D structures|Copper amine oxidase 3D structures]]
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[[Category: Amine oxidase (copper-containing)]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arthrobacter globiformis]]
[[Category: Arthrobacter globiformis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dooley, D M.]]
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[[Category: Dooley DM]]
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[[Category: Duff, A P.]]
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[[Category: Duff AP]]
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[[Category: Freeman, H C.]]
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[[Category: Freeman HC]]
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[[Category: Guss, J M.]]
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[[Category: Guss JM]]
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[[Category: Juda, G A.]]
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[[Category: Juda GA]]
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[[Category: Langley, D B.]]
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[[Category: Langley DB]]
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[[Category: Shepard, E M.]]
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[[Category: Shepard EM]]
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[[Category: Trambaiolo, D M.]]
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[[Category: Trambaiolo DM]]
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[[Category: CU]]
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[[Category: GOL]]
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[[Category: NA]]
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[[Category: SO4]]
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[[Category: 3d-structure]]
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[[Category: 3ty]]
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[[Category: amine oxidase]]
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[[Category: arthrobacter globiformi]]
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[[Category: benzylhydrazine]]
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[[Category: bh]]
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[[Category: copper]]
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[[Category: copper containing]]
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[[Category: inhibited]]
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[[Category: metal-binding]]
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[[Category: oxidoreductase]]
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[[Category: quinone]]
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[[Category: tpq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:52:38 2008''
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Current revision

AGAO covalent complex with Benzylhydrazine

PDB ID 1w5z

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