4qox

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==Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500==
==Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500==
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<StructureSection load='4qox' size='340' side='right' caption='[[4qox]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='4qox' size='340' side='right'caption='[[4qox]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qox]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QOX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QOX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DXR:3-(3-BROMOBENZYL)-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>DXR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.748&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXR:3-(3-BROMOBENZYL)-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE'>DXR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qox OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qox RCSB], [http://www.ebi.ac.uk/pdbsum/4qox PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qox OCA], [https://pdbe.org/4qox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qox RCSB], [https://www.ebi.ac.uk/pdbsum/4qox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qox ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CDPK4_PLAF7 CDPK4_PLAF7]] Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
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[https://www.uniprot.org/uniprot/CDPK4_PLAF7 CDPK4_PLAF7] Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
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==See Also==
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*[[Calcium-dependent protein kinase|Calcium-dependent protein kinase]]
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Amani, M]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Arrowsmith, C H]]
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[[Category: Amani M]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: He, H]]
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[[Category: Edwards AM]]
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[[Category: Hui, R]]
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[[Category: He H]]
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[[Category: Hutchinson, A]]
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[[Category: Hui R]]
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[[Category: Lin, Y H]]
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[[Category: Hutchinson A]]
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[[Category: Loppnau, P]]
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[[Category: Lin YH]]
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[[Category: Lovato, D V]]
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[[Category: Loppnau P]]
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[[Category: Neculai, M]]
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[[Category: Lovato DV]]
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[[Category: Ravichandran, M]]
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[[Category: Neculai M]]
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[[Category: Structural genomic]]
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[[Category: Ravichandran M]]
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[[Category: Seitova, A]]
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[[Category: Seitova A]]
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[[Category: Walker, J R]]
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[[Category: Walker JR]]
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[[Category: Wernimont, A K]]
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[[Category: Wernimont AK]]
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[[Category: Cdpk]]
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[[Category: Malaria]]
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[[Category: Plasmodium]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of CDPK4 from Plasmodium Falciparum, PF3D7_0717500

PDB ID 4qox

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