4xcx

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'''Unreleased structure'''
 
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The entry 4xcx is ON HOLD
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==METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE==
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<StructureSection load='4xcx' size='340' side='right'caption='[[4xcx]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
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Authors: Walker, J.R., Zeng, H., Dong, A., Li, Y., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., STRUCTURAL GENOMICS CONSORTIUM (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XCX FirstGlance]. <br>
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Description: METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xcx OCA], [https://pdbe.org/4xcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xcx RCSB], [https://www.ebi.ac.uk/pdbsum/4xcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xcx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Li Y]]
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[[Category: Walker JR]]
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[[Category: Wernimont A]]
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[[Category: Wu H]]
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[[Category: Zeng H]]

Current revision

METHYLTRANSFERASE DOMAIN OF SMALL RNA 2'-O-METHYLTRANSFERASE

PDB ID 4xcx

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