This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4tt4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:22, 27 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==
==Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide==
-
<StructureSection load='4tt4' size='340' side='right' caption='[[4tt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+
<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tt2|4tt2]], [[4tt6|4tt6]], [[4tte|4tte]], [[4tu4|4tu4]], [[4tu6|4tu6]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tt4 PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
+
[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4tt4" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adenosinetriphosphatase]]
+
[[Category: Homo sapiens]]
-
[[Category: Andersen, J]]
+
[[Category: Large Structures]]
-
[[Category: Bardenhagen, J]]
+
[[Category: Andersen J]]
-
[[Category: Cardozo, M]]
+
[[Category: Bardenhagen J]]
-
[[Category: Do, M Geck]]
+
[[Category: Cardozo M]]
-
[[Category: Jones, P]]
+
[[Category: Geck Do M]]
-
[[Category: Ladbury, J]]
+
[[Category: Jones P]]
-
[[Category: Lee, G]]
+
[[Category: Ladbury J]]
-
[[Category: Leo, E]]
+
[[Category: Lee G]]
-
[[Category: Leonard, P]]
+
[[Category: Leo E]]
-
[[Category: Palmer, W]]
+
[[Category: Leonard P]]
-
[[Category: Petrocchi, A]]
+
[[Category: Palmer W]]
-
[[Category: Poncet-Montange, G]]
+
[[Category: Petrocchi A]]
-
[[Category: Shi, X]]
+
[[Category: Poncet-Montange G]]
-
[[Category: Zhan, Y]]
+
[[Category: Shi X]]
-
[[Category: Bromodomain-acetylated histone complex]]
+
[[Category: Zhan Y]]
-
[[Category: Gene regulation]]
+

Current revision

Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide

PDB ID 4tt4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4tt4"
Personal tools