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4clb
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==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH IBET-295== | ==N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH IBET-295== | ||
| - | <StructureSection load='4clb' size='340' side='right' caption='[[4clb]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='4clb' size='340' side='right'caption='[[4clb]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4clb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLB OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4clb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CLB FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83T:PROPAN-2-YL+N-[(2S,4R)-1-ETHANOYL-2-METHYL-6-[4-(METHYLAMINOMETHYL)PHENYL]-3,4-DIHYDRO-2H-QUINOLIN-4-YL]CARBAMATE'>83T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=83T:PROPAN-2-YL+N-[(2S,4R)-1-ETHANOYL-2-METHYL-6-[4-(METHYLAMINOMETHYL)PHENYL]-3,4-DIHYDRO-2H-QUINOLIN-4-YL]CARBAMATE'>83T</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4clb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4clb OCA], [https://pdbe.org/4clb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4clb RCSB], [https://www.ebi.ac.uk/pdbsum/4clb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4clb ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). |
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Atkinson S]] |
| + | [[Category: Chung C]] | ||
Current revision
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH IBET-295
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