4d7c
From Proteopedia
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==Monoclinic crystal form of the extracellular olfactomedin domain from gliomedin== | ==Monoclinic crystal form of the extracellular olfactomedin domain from gliomedin== | ||
| - | <StructureSection load='4d7c' size='340' side='right' caption='[[4d7c]], [[Resolution|resolution]] 1.45Å' scene=''> | + | <StructureSection load='4d7c' size='340' side='right'caption='[[4d7c]], [[Resolution|resolution]] 1.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4d7c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7C OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4d7c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D7C FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d7c OCA], [https://pdbe.org/4d7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d7c RCSB], [https://www.ebi.ac.uk/pdbsum/4d7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d7c ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLDN_RAT GLDN_RAT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | All members of the olfactomedin (OLF) family have a conserved extracellular OLF domain, for which a structure has not been available. We present here the crystal structure of the OLF domain from gliomedin. Gliomedin is a protein expressed by Schwann cells in peripheral nerves, important for the formation of the nodes of Ranvier. Gliomedin interacts with neuronal cell adhesion molecules, such as neurofascin, but the structural details of the interaction are not known. The structure of the OLF domain presents a 5-bladed beta-propeller fold, with unusual geometric properties. The symmetry of the structure is not 5-fold, but rather, reveals a twisted arrangement. The conserved top face of the gliomedin OLF domain is likely to be important for binding to neuronal ligands. Our results provide a structural basis for the functions of gliomedin in Schwann cells, enable the understanding of the role of the gliomedin OLF domain in autoimmune neuropathies, and unravel the locations of human disease-causing mutations in other OLF family members, including myocilin. | ||
| + | |||
| + | The Olfactomedin Domain from Gliomedin is a beta-Propeller with Unique Structural Properties.,Han H, Kursula P J Biol Chem. 2014 Dec 17. pii: jbc.M114.627547. PMID:25525261<ref>PMID:25525261</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4d7c" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Han H]] |
| - | [[Category: | + | [[Category: Kursula P]] |
| - | + | ||
Current revision
Monoclinic crystal form of the extracellular olfactomedin domain from gliomedin
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