4nnh

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==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==
==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==
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<StructureSection load='4nnh' size='340' side='right' caption='[[4nnh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4nnh' size='340' side='right'caption='[[4nnh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nnh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNH FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nng|4nng]], [[4nni|4nni]], [[4nnk|4nnk]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nnh RCSB], [http://www.ebi.ac.uk/pdbsum/4nnh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnh OCA], [https://pdbe.org/4nnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nnh RCSB], [https://www.ebi.ac.uk/pdbsum/4nnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nnh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0QYY6_MYCS2 A0QYY6_MYCS2]] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.[PIRNR:PIRNR002111]
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[https://www.uniprot.org/uniprot/RS1_MYCS2 RS1_MYCS2] Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Plays a role in trans-translation; binds tmRNA (the product of the ssrA gene) (PubMed:25430994). Binds very poorly to pyrazinoic acid (POA), the active form of the prodrug pyrazinamide (PZA); POA does not disrupt trans-translation in this organism (PubMed:21835980). M.smegmatis is resistant to the antibiotic PZA (PubMed:25430994). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and thus targeted for degradation.[UniProtKB:P0AG67]<ref>PMID:21835980</ref> <ref>PMID:25430994</ref>
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==See Also==
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*[[Ribosomal protein S1|Ribosomal protein S1]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cai, Q]]
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[[Category: Large Structures]]
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[[Category: Lin, D]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Liu, Y]]
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[[Category: Cai Q]]
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[[Category: Yang, J]]
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[[Category: Lin D]]
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[[Category: Beta barrel]]
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[[Category: Liu Y]]
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[[Category: Ribosomal protein]]
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[[Category: Yang J]]

Current revision

Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide

PDB ID 4nnh

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