We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
4rnb
From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | ==Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant==
| + | #REDIRECT [[4s0v]] This PDB entry is obsolete and replaced by 4s0v |
| - | <StructureSection load='4rnb' size='340' side='right' caption='[[4rnb]], [[Resolution|resolution]] 2.50Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[4rnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RNB FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rnb RCSB], [http://www.ebi.ac.uk/pdbsum/4rnb PDBsum]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN]] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Kolb, P]]
| + | |
| - | [[Category: Mobarec, J C]]
| + | |
| - | [[Category: Rosenbaum, D M]]
| + | |
| - | [[Category: Yin, J]]
| + | |
| - | [[Category: G protein-coupled receptor]]
| + | |
| - | [[Category: N-linked glycosylation]]
| + | |
| - | [[Category: Orexin neurotransmitter]]
| + | |
| - | [[Category: Orexin-a]]
| + | |
| - | [[Category: Orexin-b]]
| + | |
| - | [[Category: Signaling protein]]
| + | |
| - | [[Category: Suvorexant]]
| + | |
Current revision
- REDIRECT 4s0v This PDB entry is obsolete and replaced by 4s0v
