4tr8

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==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa==
==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa==
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<StructureSection load='4tr8' size='340' side='right' caption='[[4tr8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4tr8' size='340' side='right'caption='[[4tr8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tr8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TR8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_HB15 Pseudomonas aeruginosa HB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TR8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tr8 RCSB], [http://www.ebi.ac.uk/pdbsum/4tr8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tr8 OCA], [https://pdbe.org/4tr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tr8 RCSB], [https://www.ebi.ac.uk/pdbsum/4tr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tr8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/V4MZL6_PSEAI V4MZL6_PSEAI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).[PIRNR:PIRNR000804]
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[https://www.uniprot.org/uniprot/DPO3B_PSEAE DPO3B_PSEAE] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tr8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Burnouf, D]]
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[[Category: Pseudomonas aeruginosa HB15]]
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[[Category: Ennifar, E]]
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[[Category: Burnouf D]]
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[[Category: Olieric, V]]
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[[Category: Ennifar E]]
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[[Category: Wolff, P]]
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[[Category: Olieric V]]
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[[Category: Dna binding protein]]
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[[Category: Wolff P]]
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[[Category: Dna polymerase]]
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[[Category: Processivity]]
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[[Category: Sliding clamp]]
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Current revision

Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa

PDB ID 4tr8

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