2mjy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of synthetic Mamba-1 peptide== | |
| + | <StructureSection load='2mjy' size='340' side='right'caption='[[2mjy]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjy OCA], [https://pdbe.org/2mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjy RCSB], [https://www.ebi.ac.uk/pdbsum/2mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/3SX1_DENPO 3SX1_DENPO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation. Synthetic Mambalgin-1 exhibited a well-defined structure after sequential folding in vitro. NMR spectroscopy revealed a three-finger toxin family structure, and the synthetic toxin inhibited human acid-sensing ion channel 1a. | ||
| - | + | One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1.,Pan M, He Y, Wen M, Wu F, Sun D, Li S, Zhang L, Li Y, Tian C Chem Commun (Camb). 2014 Jun 4;50(44):5837-9. doi: 10.1039/c4cc00779d. PMID:24619065<ref>PMID:24619065</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2mjy" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dendroaspis polylepis polylepis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: He Y]] | ||
| + | [[Category: Tian C]] | ||
| + | [[Category: Wu F]] | ||
Current revision
Solution structure of synthetic Mamba-1 peptide
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