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2mrp

From Proteopedia

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'''Unreleased structure'''
 
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The entry 2mrp is ON HOLD
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==NMR solution structure of the Ubiquitin like domain (UBL) of DNA-damage-inducible 1 protein (Ddi1)==
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<StructureSection load='2mrp' size='340' side='right'caption='[[2mrp]]' scene=''>
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Authors: Nowicka, U., Fushman, D., Chen, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2mrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MRP FirstGlance]. <br>
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Description: NMR solution structure of the Ubiquitin like domain (UBL) of DNA-damage-inducible 1 protein (Ddi1)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mrp OCA], [https://pdbe.org/2mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mrp RCSB], [https://www.ebi.ac.uk/pdbsum/2mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mrp ProSAT]</span></td></tr>
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[[Category: Fushman, D]]
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</table>
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[[Category: Chen, T]]
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== Function ==
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[[Category: Nowicka, U]]
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[https://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Chen T]]
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[[Category: Fushman D]]
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[[Category: Nowicka U]]

Current revision

NMR solution structure of the Ubiquitin like domain (UBL) of DNA-damage-inducible 1 protein (Ddi1)

PDB ID 2mrp

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