3j9b
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Electron cryo-microscopy of an RNA polymerase== | |
| + | <SX load='3j9b' size='340' side='right' viewer='molstar' caption='[[3j9b]], [[Resolution|resolution]] 4.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3j9b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1)) Influenza A virus (A/goose/Guangdong/1/1996(H5N1))], [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/3/1997(H5N1)) Influenza A virus (A/goose/Guangdong/3/1997(H5N1))] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J9B FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9b OCA], [https://pdbe.org/3j9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j9b RCSB], [https://www.ebi.ac.uk/pdbsum/3j9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q91R78_9INFA Q91R78_9INFA] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063] | ||
| - | + | ==See Also== | |
| - | + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </SX> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Boruah BM]] | ||
| + | [[Category: Chang SH]] | ||
| + | [[Category: Feng F]] | ||
| + | [[Category: Guan CC]] | ||
| + | [[Category: Guo L]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Liang HH]] | ||
| + | [[Category: Liu YF]] | ||
| + | [[Category: Sun DP]] | ||
| + | [[Category: Wang HW]] | ||
| + | [[Category: Wang J]] | ||
| + | [[Category: Wang JW]] | ||
| + | [[Category: Wang MT]] | ||
| + | [[Category: Wang XL]] | ||
| + | [[Category: Wojdyla J]] | ||
| + | [[Category: Yang MR]] | ||
| + | [[Category: Yuan LM]] | ||
Current revision
Electron cryo-microscopy of an RNA polymerase
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