2r4r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:28, 6 November 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of the human beta2 adrenoceptor==
==Crystal structure of the human beta2 adrenoceptor==
-
<StructureSection load='2r4r' size='340' side='right' caption='[[2r4r]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+
<StructureSection load='2r4r' size='340' side='right'caption='[[2r4r]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R4R FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4R FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r4s|2r4s]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADRB2, ADRB2R, B2AR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [https://pdbe.org/2r4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [https://www.ebi.ac.uk/pdbsum/2r4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4r ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [http://www.ebi.ac.uk/pdbsum/2r4r PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
+
[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4r ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 27: Line 27:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2r4r" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
*[[Adrenergic receptor|Adrenergic receptor]]
*[[Adrenergic receptor|Adrenergic receptor]]
 +
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
*[[G protein-coupled receptor|G protein-coupled receptor]]
*[[G protein-coupled receptor|G protein-coupled receptor]]
-
*[[Monoclonal Antibody|Monoclonal Antibody]]
+
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
-
*[[Nobel Prizes for 3D Molecular Structure|Nobel Prizes for 3D Molecular Structure]]
+
== References ==
== References ==
<references/>
<references/>
Line 39: Line 40:
[[Category: Adrenergic Receptors]]
[[Category: Adrenergic Receptors]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
-
[[Category: Burghammer, M]]
+
[[Category: Burghammer M]]
-
[[Category: Choi, H J]]
+
[[Category: Choi HJ]]
-
[[Category: Edwards, P C]]
+
[[Category: Edwards PC]]
-
[[Category: Fischetti, R F]]
+
[[Category: Fischetti RF]]
-
[[Category: Kobilka, B K]]
+
[[Category: Kobilka BK]]
-
[[Category: Kobilka, T S]]
+
[[Category: Kobilka TS]]
-
[[Category: Rasmussen, S G.F]]
+
[[Category: Rasmussen SGF]]
-
[[Category: Ratnala, V R]]
+
[[Category: Ratnala VR]]
-
[[Category: Rosenbaum, D M]]
+
[[Category: Rosenbaum DM]]
-
[[Category: Sanishvili, R]]
+
[[Category: Sanishvili R]]
-
[[Category: Schertler, G F]]
+
[[Category: Schertler GF]]
-
[[Category: Thian, F S]]
+
[[Category: Thian FS]]
-
[[Category: Weis, W I]]
+
[[Category: Weis WI]]
-
[[Category: G-protein coupled receptor]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Palmitate]]
+
-
[[Category: Phosphorylation]]
+
-
[[Category: Receptor]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Transducer]]
+
-
[[Category: Transmembrane helix]]
+

Current revision

Crystal structure of the human beta2 adrenoceptor

PDB ID 2r4r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2r4r"
Personal tools