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1wyr

From Proteopedia

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[[Image:1wyr.gif|left|200px]]
 
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{{Structure
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==Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6==
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|PDB= 1wyr |SIZE=350|CAPTION= <scene name='initialview01'>1wyr</scene>
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<StructureSection load='1wyr' size='340' side='right'caption='[[1wyr]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1wyr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WYR FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= ARHGEF6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyr OCA], [https://pdbe.org/1wyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wyr RCSB], [https://www.ebi.ac.uk/pdbsum/1wyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wyr ProSAT], [https://www.topsan.org/Proteins/RSGI/1wyr TOPSAN]</span></td></tr>
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}}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/1wyr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wyr ConSurf].
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<div style="clear:both"></div>
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'''Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6'''
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==See Also==
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known diseases associated with this structure: Mental retardation, X-linked nonspecific, type 46 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300267 300267]]
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__TOC__
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</StructureSection>
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==About this Structure==
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1WYR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WYR OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tomizawa T]]
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[[Category: Tomizawa, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: all-alpha]]
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[[Category: ch domain]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:03:11 2008''
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Current revision

Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6

PDB ID 1wyr

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