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3hy4

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==Structure of human MTHFS with N5-iminium phosphate==
==Structure of human MTHFS with N5-iminium phosphate==
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<StructureSection load='3hy4' size='340' side='right' caption='[[3hy4]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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<StructureSection load='3hy4' size='340' side='right'caption='[[3hy4]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3hy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HY4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3hy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HY4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N5G:N-({TRANS-4-[({(2R,4R,4AS,6S,8AS)-2-AMINO-4-HYDROXY-5-[(PHOSPHONOOXY)METHYL]DECAHYDROPTERIDIN-6-YL}METHYL)AMINO]CYCLOHEXYL}CARBONYL)-L-GLUTAMIC+ACID'>N5G</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.795&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hxt|3hxt]], [[3hy3|3hy3]], [[3hy6|3hy6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N5G:N-({TRANS-4-[({(2R,4R,4AS,6S,8AS)-2-AMINO-4-HYDROXY-5-[(PHOSPHONOOXY)METHYL]DECAHYDROPTERIDIN-6-YL}METHYL)AMINO]CYCLOHEXYL}CARBONYL)-L-GLUTAMIC+ACID'>N5G</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTHFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy4 OCA], [https://pdbe.org/3hy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hy4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hy4 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hy4 RCSB], [http://www.ebi.ac.uk/pdbsum/3hy4 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MTHFS_HUMAN MTHFS_HUMAN]] Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
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[https://www.uniprot.org/uniprot/MTHFS_HUMAN MTHFS_HUMAN] Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hy4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hy4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hy4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3hy4" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cheng, C]]
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[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Cheng C]]
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[[Category: Liu, Z J]]
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[[Category: Li Y]]
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[[Category: Shaw, N]]
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[[Category: Liu Z-J]]
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[[Category: Song, G]]
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[[Category: Shaw N]]
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[[Category: Wu, D]]
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[[Category: Song G]]
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[[Category: Antifolate]]
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[[Category: Wu D]]
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[[Category: Atp-binding]]
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[[Category: Cancer]]
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[[Category: Folate-binding]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: N5-iminium phosphate]]
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[[Category: Nucleotide-binding]]
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Current revision

Structure of human MTHFS with N5-iminium phosphate

PDB ID 3hy4

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