4nqw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:43, 11 January 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
 +
==Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA==
==Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA==
-
<StructureSection load='4nqw' size='340' side='right' caption='[[4nqw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+
<StructureSection load='4nqw' size='340' side='right'caption='[[4nqw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4nqw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4nqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3vdo 3vdo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQW FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0445c, sigK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), rskA, Rv0444c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqw OCA], [https://pdbe.org/4nqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nqw RCSB], [https://www.ebi.ac.uk/pdbsum/4nqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nqw ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nqw RCSB], [http://www.ebi.ac.uk/pdbsum/4nqw PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83. [[http://www.uniprot.org/uniprot/RSKA_MYCTU RSKA_MYCTU]] Represses SigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of SigK-regulated genes, such as mpt70 and mpt83.
+
[https://www.uniprot.org/uniprot/SIGK_MYCTU SIGK_MYCTU] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-K controls genes such as mpt70 and mpt83.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 17: Line 17:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4nqw" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Sigma factor|Sigma factor]]
+
*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Gopal, B]]
+
[[Category: Large Structures]]
-
[[Category: Shukla, J K]]
+
[[Category: Mycobacterium tuberculosis]]
-
[[Category: Anti-sigma factor]]
+
[[Category: Gopal B]]
-
[[Category: Dna binding]]
+
[[Category: Shukla JK]]
-
[[Category: Dna binding protein-protein binding complex]]
+
-
[[Category: Promoter dna binding and transcription initiation]]
+
-
[[Category: Sigma factor]]
+
-
[[Category: Transcription initiation]]
+

Current revision

Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA

PDB ID 4nqw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nqw"
Personal tools