3l6x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:32, 6 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of p120 catenin in complex with E-cadherin==
==Crystal structure of p120 catenin in complex with E-cadherin==
-
<StructureSection load='3l6x' size='340' side='right' caption='[[3l6x]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+
<StructureSection load='3l6x' size='340' side='right'caption='[[3l6x]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3l6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L6X FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3l6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L6X FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l6y|3l6y]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTNND1, KIAA0384 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l6x OCA], [https://pdbe.org/3l6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l6x RCSB], [https://www.ebi.ac.uk/pdbsum/3l6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l6x ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l6x RCSB], [http://www.ebi.ac.uk/pdbsum/3l6x PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CTND1_HUMAN CTND1_HUMAN]] Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.<ref>PMID:17344476</ref>
+
[https://www.uniprot.org/uniprot/CTND1_HUMAN CTND1_HUMAN] Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.<ref>PMID:17344476</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/3l6x_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l6/3l6x_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l6x ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 28: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3l6x" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Cadherin|Cadherin]]
+
*[[Catenin 3D structures|Catenin 3D structures]]
-
*[[Catenin|Catenin]]
+
== References ==
== References ==
<references/>
<references/>
Line 37: Line 37:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Ikura, M]]
+
[[Category: Large Structures]]
-
[[Category: Ishiyama, N]]
+
[[Category: Ikura M]]
-
[[Category: Lee, S H]]
+
[[Category: Ishiyama N]]
-
[[Category: Li, G Y]]
+
[[Category: Lee S-H]]
-
[[Category: Liu, S]]
+
[[Category: Li G-Y]]
-
[[Category: Reichardt, L F]]
+
[[Category: Liu S]]
-
[[Category: Smith, M J]]
+
[[Category: Reichardt LF]]
-
[[Category: Arm]]
+
[[Category: Smith MJ]]
-
[[Category: Armadillo]]
+
-
[[Category: Arvcf]]
+
-
[[Category: Cadherin]]
+
-
[[Category: Catenin]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell membrane]]
+
-
[[Category: Cell-cell adhesion]]
+
-
[[Category: Complex]]
+
-
[[Category: Delta-catenin]]
+
-
[[Category: Dp120]]
+
-
[[Category: E-cadherin]]
+
-
[[Category: Jac-1]]
+
-
[[Category: Jmd]]
+
-
[[Category: Membrane]]
+
-
[[Category: Nucleus]]
+
-
[[Category: P0071]]
+
-
[[Category: P120]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Wnt signaling pathway]]
+

Current revision

Crystal structure of p120 catenin in complex with E-cadherin

PDB ID 3l6x

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3l6x"
Personal tools