This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1x6d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:02, 9 May 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1x6d.gif|left|200px]]
 
-
{{Structure
+
==Solution structures of the PDZ domain of human Interleukin-16==
-
|PDB= 1x6d |SIZE=350|CAPTION= <scene name='initialview01'>1x6d</scene>
+
<StructureSection load='1x6d' size='340' side='right'caption='[[1x6d]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1x6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6D FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= IL16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6d OCA], [https://pdbe.org/1x6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6d RCSB], [https://www.ebi.ac.uk/pdbsum/1x6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6d TOPSAN]</span></td></tr>
-
}}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL16_HUMAN IL16_HUMAN] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x6/1x6d_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x6d ConSurf].
 +
<div style="clear:both"></div>
-
'''Solution structures of the PDZ domain of human Interleukin-16'''
+
==See Also==
-
 
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1X6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6D OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Inoue, M.]]
+
[[Category: Inoue M]]
-
[[Category: Kigawa, T.]]
+
[[Category: Kigawa T]]
-
[[Category: Koshiba, S.]]
+
[[Category: Koshiba S]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Sato M]]
-
[[Category: Sato, M.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
-
[[Category: lymphocyte chemoattractant factor (lcf)]]
+
-
[[Category: national project on protein structural and functional analyse]]
+
-
[[Category: nppsfa]]
+
-
[[Category: pdz domain]]
+
-
[[Category: riken structural genomics/proteomics initiative]]
+
-
[[Category: rsgi]]
+
-
[[Category: structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:05:42 2008''
+

Current revision

Solution structures of the PDZ domain of human Interleukin-16

PDB ID 1x6d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x6d"
Personal tools