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2jc6
From Proteopedia
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| - | [[Image:2jc6.gif|left|200px]]<br /> | ||
| - | <applet load="2jc6" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jc6, resolution 2.30Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE 1D'''<br /> | ||
| - | == | + | ==Crystal structure of human calmodulin-dependent protein kinase 1D== |
| - | + | <StructureSection load='2jc6' size='340' side='right'caption='[[2jc6]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2jc6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JC6 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QPP:N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE'>QPP</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jc6 OCA], [https://pdbe.org/2jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jc6 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | [ | + | [https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref> |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/2jc6_consurf.spt"</scriptWhenChecked> |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jc6 ConSurf]. | |
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| - | + | ==See Also== | |
| + | *[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Berridge G]] | ||
| + | [[Category: Bhatia C]] | ||
| + | [[Category: Bunkoczi G]] | ||
| + | [[Category: Colebrook S]] | ||
| + | [[Category: Debreczeni JE]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Fedorov O]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Niesen FH]] | ||
| + | [[Category: Pike ACW]] | ||
| + | [[Category: Rellos P]] | ||
| + | [[Category: Salah E]] | ||
| + | [[Category: Shrestha L]] | ||
| + | [[Category: Smee C]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human calmodulin-dependent protein kinase 1D
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berridge G | Bhatia C | Bunkoczi G | Colebrook S | Debreczeni JE | Edwards A | Fedorov O | Gileadi O | Knapp S | Niesen FH | Pike ACW | Rellos P | Salah E | Shrestha L | Smee C | Sundstrom M | Ugochukwu E | Weigelt J | Von Delft F
