4p5a

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'''Unreleased structure'''
 
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The entry 4p5a is ON HOLD until Paper Publication
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==Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP==
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<StructureSection load='4p5a' size='340' side='right'caption='[[4p5a]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4p5a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_asoensis Streptomyces asoensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P5A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5a OCA], [https://pdbe.org/4p5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p5a RCSB], [https://www.ebi.ac.uk/pdbsum/4p5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p5a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/C1IC19_9ACTN C1IC19_9ACTN] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.[HAMAP-Rule:MF_01408]
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Authors: Li, Y., Chen, W., Li, J., Xia, Z., Deng, Z., Zhou, J.
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==See Also==
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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Description: Cryatal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Xia, Z]]
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[[Category: Large Structures]]
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[[Category: Li, J]]
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[[Category: Streptomyces asoensis]]
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[[Category: Li, Y]]
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[[Category: Chen W]]
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[[Category: Chen, W]]
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[[Category: Deng Z]]
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[[Category: Zhou, J]]
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[[Category: Li J]]
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[[Category: Deng, Z]]
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[[Category: Li Y]]
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[[Category: Xia Z]]
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[[Category: Zhou J]]

Current revision

Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP

PDB ID 4p5a

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