4q1l

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'''Unreleased structure'''
 
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The entry 4q1l is ON HOLD until Paper Publication
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==Crystal structure of Leucurolysin-a complexed with an endogenous tripeptide (QSW).==
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<StructureSection load='4q1l' size='340' side='right'caption='[[4q1l]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Ferreira, R.N., Sanchez, E.O.F., Pimenta, A.M.C., Nagem, R.A.P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q1l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_leucurus Bothrops leucurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q1L FirstGlance]. <br>
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Description: Crystal structure of Leucurolysin-a complexed with an endogenous tripeptide (QSW).
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Sanchez, E.O.F]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1l OCA], [https://pdbe.org/4q1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q1l RCSB], [https://www.ebi.ac.uk/pdbsum/4q1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1l ProSAT]</span></td></tr>
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[[Category: Nagem, R.A.P]]
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</table>
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[[Category: Ferreira, R.N]]
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== Function ==
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[[Category: Pimenta, A.M.C]]
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[https://www.uniprot.org/uniprot/VM1LA_BOTLC VM1LA_BOTLC] Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also observed. Induces detachment of endothelial cells followed by death, and inhibits endothelial cell adhesion to fibronectin. Induces edema in mouse paw. Inhibits ADP-induced platelet aggregation on human platelet-rich plasma with an IC(50) of 2.8 uM.<ref>PMID:16139412</ref> <ref>PMID:17482228</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bothrops leucurus]]
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[[Category: Large Structures]]
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[[Category: Ferreira RN]]
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[[Category: Nagem RAP]]
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[[Category: Pimenta AMC]]
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[[Category: Sanchez EOF]]

Current revision

Crystal structure of Leucurolysin-a complexed with an endogenous tripeptide (QSW).

PDB ID 4q1l

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