4q45

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'''Unreleased structure'''
 
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The entry 4q45 is ON HOLD
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==DNA Polymerase- damaged DNA complex==
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<StructureSection load='4q45' size='340' side='right'caption='[[4q45]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4q45]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q45 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.176&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FZ:5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]AMINO}PHOSPHORYL]THYMIDINE'>1FZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RDG:2-DEOXY-N-(FURAN-2-YLMETHYL)GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>RDG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q45 OCA], [https://pdbe.org/4q45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q45 RCSB], [https://www.ebi.ac.uk/pdbsum/4q45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q45 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO4_ECOLI DPO4_ECOLI] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.<ref>PMID:9391106</ref> <ref>PMID:11080171</ref> <ref>PMID:11463382</ref> <ref>PMID:11751576</ref> <ref>PMID:12060704</ref>
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Authors: Kottur, J., Sharma, A., Nair, D.T.
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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Description: DNA Polymerase-damaged DNA complex
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Nair, D.T]]
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__TOC__
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[[Category: Sharma, A]]
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</StructureSection>
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[[Category: Kottur, J]]
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Kottur J]]
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[[Category: Nair DT]]
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[[Category: Sharma A]]

Current revision

DNA Polymerase- damaged DNA complex

PDB ID 4q45

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OCA

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