4qbw

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'''Unreleased structure'''
 
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The entry 4qbw is ON HOLD until Paper Publication
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==The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop==
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<StructureSection load='4qbw' size='340' side='right'caption='[[4qbw]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QBW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.912&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbw OCA], [https://pdbe.org/4qbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qbw RCSB], [https://www.ebi.ac.uk/pdbsum/4qbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qbw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
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Authors: Xiao, P., Wang, X., Wang, H.M., Fu, X.L., Cui, F.A., Yu, X., Bi, W.X., Sun, J.P.
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==See Also==
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
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Description: The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Yu, X]]
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__TOC__
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[[Category: Sun, J.P]]
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</StructureSection>
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[[Category: Wang, H.M]]
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[[Category: Homo sapiens]]
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[[Category: Cui, F.A]]
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[[Category: Large Structures]]
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[[Category: Fu, X.L]]
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[[Category: Bi WX]]
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[[Category: Bi, W.X]]
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[[Category: Cui FA]]
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[[Category: Xiao, P]]
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[[Category: Fu XL]]
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[[Category: Wang, X]]
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[[Category: Sun JP]]
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[[Category: Wang HM]]
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[[Category: Wang X]]
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[[Category: Xiao P]]
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[[Category: Yu X]]

Current revision

The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop

PDB ID 4qbw

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