1xpi

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[[Image:1xpi.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the catalytic domain of E. coli pseudouridine synthase RluC==
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|PDB= 1xpi |SIZE=350|CAPTION= <scene name='initialview01'>1xpi</scene>, resolution 2.20&Aring;
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<StructureSection load='1xpi' size='340' side='right'caption='[[1xpi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
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<table><tr><td colspan='2'>[[1xpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPI FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE= rluC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpi OCA], [https://pdbe.org/1xpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpi RCSB], [https://www.ebi.ac.uk/pdbsum/1xpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RLUC_ECOLI RLUC_ECOLI] Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpi ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the catalytic domain of E. coli pseudouridine synthase RluC'''
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==See Also==
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*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]]
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*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
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==About this Structure==
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__TOC__
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1XPI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPI OCA].
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Pseudouridylate synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Del Campo M]]
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[[Category: Campo, M Del.]]
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[[Category: Fenna R]]
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[[Category: Fenna, R.]]
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[[Category: Malhotra A]]
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[[Category: Malhotra, A.]]
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[[Category: Ofengand J]]
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[[Category: Ofengand, J.]]
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[[Category: ACY]]
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[[Category: catalytic domain]]
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[[Category: pseudouridine synthase]]
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[[Category: rluc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:50 2008''
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Current revision

Crystal structure of the catalytic domain of E. coli pseudouridine synthase RluC

PDB ID 1xpi

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