4qkh

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'''Unreleased structure'''
 
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The entry 4qkh is ON HOLD
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==Dimeric form of human LLT1, a ligand for NKR-P1==
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<StructureSection load='4qkh' size='340' side='right'caption='[[4qkh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qkh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QKH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkh OCA], [https://pdbe.org/4qkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qkh RCSB], [https://www.ebi.ac.uk/pdbsum/4qkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qkh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CLC2D_HUMAN CLC2D_HUMAN] Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.<ref>PMID:14753741</ref> <ref>PMID:15104121</ref> <ref>PMID:16339513</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human LLT1 is a C-type lectin-like ligand of NKR-P1 (CD161, gene KLRB1), a C-type lectin-like receptor of natural killer cells. Using X-ray diffraction, the first experimental structures of human LLT1 were determined. Four structures of LLT1 under various conditions were determined: monomeric, dimeric deglycosylated after the first N-acetylglucosamine unit in two forms and hexameric with homogeneous GlcNAc2Man5 glycosylation. The dimeric form follows the classical dimerization mode of human CD69. The monomeric form keeps the same fold with the exception of the position of an outer part of the long loop region. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin-like proteins in the glycosylated form.
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Authors: Skalova, T., Blaha, J., Harlos, K., Duskova, J., Koval, T., Stransky, J., Hasek, J., Vanek, O., Dohnalek, J.
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Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states.,Skalova T, Blaha J, Harlos K, Duskova J, Koval' T, Stransky J, Hasek J, Vanek O, Dohnalek J Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):578-91. doi:, 10.1107/S1399004714027928. Epub 2015 Feb 26. PMID:25760607<ref>PMID:25760607</ref>
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Description: Dimeric form of human LLT1, a ligand for NKR-P1
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Dohnalek, J]]
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<div class="pdbe-citations 4qkh" style="background-color:#fffaf0;"></div>
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[[Category: Duskova, J]]
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== References ==
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[[Category: Harlos, K]]
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<references/>
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[[Category: Stransky, J]]
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__TOC__
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[[Category: Blaha, J]]
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</StructureSection>
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[[Category: Vanek, O]]
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[[Category: Homo sapiens]]
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[[Category: Hasek, J]]
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[[Category: Large Structures]]
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[[Category: Koval, T]]
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[[Category: Blaha J]]
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[[Category: Skalova, T]]
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[[Category: Dohnalek J]]
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[[Category: Duskova J]]
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[[Category: Harlos K]]
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[[Category: Hasek J]]
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[[Category: Koval T]]
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[[Category: Skalova T]]
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[[Category: Stransky J]]
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[[Category: Vanek O]]

Current revision

Dimeric form of human LLT1, a ligand for NKR-P1

PDB ID 4qkh

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