4qwq

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'''Unreleased structure'''
 
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The entry 4qwq is ON HOLD
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==Crystal structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus==
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<StructureSection load='4qwq' size='340' side='right'caption='[[4qwq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4qwq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QWQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qwq OCA], [https://pdbe.org/4qwq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qwq RCSB], [https://www.ebi.ac.uk/pdbsum/4qwq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qwq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAER_STAA8 SAER_STAA8] Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall-associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory cascade of virulence factors.<ref>PMID:10436918</ref> <ref>PMID:11442841</ref> <ref>PMID:14523104</ref> <ref>PMID:14563862</ref> <ref>PMID:15941988</ref> <ref>PMID:17041853</ref> <ref>PMID:7922890</ref> <ref>PMID:8742355</ref> <ref>PMID:9211714</ref>
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Authors: Fan, X., Zhu, Y., Zhang, X., Teng, M., Li, X.
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==See Also==
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*[[Response regulator 3D structure|Response regulator 3D structure]]
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Description: Crystal structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Teng, M]]
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__TOC__
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[[Category: Zhu, Y]]
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</StructureSection>
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[[Category: Li, X]]
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[[Category: Large Structures]]
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[[Category: Zhang, X]]
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[[Category: Staphylococcus aureus]]
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[[Category: Fan, X]]
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[[Category: Fan X]]
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[[Category: Li X]]
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[[Category: Teng M]]
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[[Category: Zhang X]]
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[[Category: Zhu Y]]

Current revision

Crystal structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus

PDB ID 4qwq

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OCA

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