4pbw

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==Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC==
==Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC==
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<StructureSection load='4pbw' size='340' side='right' caption='[[4pbw]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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<StructureSection load='4pbw' size='340' side='right'caption='[[4pbw]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pbw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PBW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pbw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PBW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yd4|2yd4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pbw OCA], [https://pdbe.org/4pbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pbw RCSB], [https://www.ebi.ac.uk/pdbsum/4pbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pbw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pbw RCSB], [http://www.ebi.ac.uk/pdbsum/4pbw PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NTRK3_CHICK NTRK3_CHICK]] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase and PLCG1. The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells.
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[https://www.uniprot.org/uniprot/NTRK3_CHICK NTRK3_CHICK] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase and PLCG1. The KT and KD isoforms fail to stimulate transformation, process outgrowth or survival. Isoform KI25 exhibits tyrosine phosphorylation in the absence of ligand and is unable to mediate survival of neuronal cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4pbw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[TrkB tyrosine kinase receptor|TrkB tyrosine kinase receptor]]
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*[[Tyrosine kinase receptor|Tyrosine kinase receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Gallus gallus]]
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[[Category: Aricescu, A R]]
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[[Category: Large Structures]]
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[[Category: Coles, C H]]
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[[Category: Aricescu AR]]
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[[Category: Craig, A M]]
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[[Category: Coles CH]]
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[[Category: Elegheert, J]]
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[[Category: Craig AM]]
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[[Category: Jones, E Y]]
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[[Category: Elegheert J]]
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[[Category: Lu, W]]
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[[Category: Jones EY]]
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[[Category: Mitakidis, N]]
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[[Category: Lu W]]
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[[Category: Nakagawa, T]]
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[[Category: Mitakidis N]]
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[[Category: Stoker, A W]]
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[[Category: Nakagawa T]]
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[[Category: Zhang, P]]
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[[Category: Stoker AW]]
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[[Category: Signaling protein]]
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[[Category: Zhang P]]
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[[Category: Synapse cell signalling cell surface receptor]]
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Current revision

Crystal structure of chicken receptor protein tyrosine phosphatase sigma in complex with TrkC

PDB ID 4pbw

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